Nature has published an article titled "Move over, AlphaFold: open source model predicts shape of 1 billion proteins." This article was published online on 27 May 2026 and is identified by the specific DOI 10.1038/d41586-026-01686-3. The publication addresses a significant development in the field of biological research regarding protein structures.
The report introduces a new open-source atlas generated by an artificial intelligence tool called ESMFold2. According to the summary provided by Nature, this atlas vastly increases the known protein universe. The AI tool, ESMFold2, is responsible for predicting the shape of 1 billion proteins. This massive scale of prediction is the central achievement highlighted in the news piece.
The title of the article explicitly references AlphaFold, placing the new development in context with existing technology. However, the focus remains on the capabilities of ESMFold2 and the open-source atlas it produced. The prediction of 1 billion protein shapes represents a vast increase in scientific knowledge. By releasing this data, the new atlas expands the known protein universe significantly. The article provides the scientific community with details on how ESMFold2 has contributed to this expansion. The publication date of 27 May 2026 and the DOI 10.1038/d41586-026-01686-3 serve as the official record for this announcement.
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